HRS 2019: MADIT trials analysis shows decline in sudden cardiac deaths “likely due to CRT”


Valentina Kutyifa (Rochester, USA) discusses the late-breaking study findings looking at data from the family of MADIT (Multicenter Automatic Defibrillator) trials.

Kutyifa told Cardiac Rhythm News that the key takeaway from the analysis of the trials’ data was that cardiac resynchronisation therapy (CRT) was found to be “associated with a reduction in the risk of life-threatening ventricular arrhythmia events.”

A sub-group analysis of the trials focusing on patients that had narrow QRS and an indication for an ICD (implantable cardioverter-defibrillator) showed that there was “no difference in the rate of life-threatening ventricular arrhythmias in the earlier MADIT studies compared with the later studies”. Despite these findings however, Kutyifa notes that ICD is “still a very valuable therapy for patients with a narrow QRS to save lives from sudden cardiac death”.

According to Kutyifa the study is “really important” because it shows that the decline of sudden cardiac deaths and potential ventricular arrhythmia events is “likely due to CRT devices”.


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