Data reinforce benefits of Medtronic cardiac resynchronisation therapy technologies in ‘real-world’ setting


New data supporting the clinical performance of the company’s exclusive EffectivCRT diagnostic and AdaptivCRT algorithm in heart failure patients who receive cardiac resynchronisation therapy (CRT) devices have been presented at Heart Rhythm 2017, the Heart Rhythm Society’s 38th Annual Scientific Sessions in Chicago, USA.

Many CRT devices report “percent pacing”, however, they do not report the effectiveness of each pacing stimulus. The EffectivCRT diagnostic—available on the newest Medtronic CRT-defibrillators and CRT-pacemakers—automatically determines the effectiveness of left ventricular pacing.

Chris Plummer of Freeman Hospital, Newcastle-on-Tyne, UK, presented an analysis of 335 patients implanted with a Claria MRI CRT-D SureScan, which is designed to provide diagnostics to help determine the cause of ineffective pacing.

Additionally, a large (40,000+ patients) observational study compared the risk of developing atrial fibrillation (AF) in patients with CRT-Ds treated with AdaptivCRT vs standard biventricular pacing. Patients treated with AdaptivCRT experienced a 35% reduction in the subsequent development of AF compared to patients treated with standard biventricular pacing. The data presented at Heart Rhythm 2017 are consistent with previous findings from the randomised Adaptive CRT clinical trial, which demonstrated a 46% reduction in the risk of developing AF.

“These outcomes further confirm the benefits of these advanced cardiac resynchronisation therapy technologies delivered in a contemporary real-world clinical setting,” says Jonathan Hsu, cardiac electrophysiologist and assistant professor of medicine at the University of California, San Diego, USA. “AdaptivCRT gives us more insights and automatically makes adjustments based on each patient’s unique needs, and our study suggests that its use is associated with a decreased risk of developing atrial fibrillation.”

The AdaptivCRT algorithm is designed to adjust the way devices stimulate the heart according to minute-to-minute evaluations of each patient’s rhythm. The Percepta Quad CRT-P also features the EffectivCRT diagnostic.