Quitting cigarettes can significantly lower a person’s risk of atrial fibrillation (AF) compared to those who continue to smoke, according to a study published recently in the Journal of the American College of Cardiology (JACC): Clinical Electrophysiology. The findings show that the benefits of quitting start right away, suggesting that it is possible to reverse the risk of negative health outcomes.
“The findings provide a compelling new reason to show current smokers that it’s not too late to quit and that having smoked in the past doesn’t mean you’re ‘destined’ to develop AF,” said senior author Gregory Marcus (University of California San Francisco [UCSF], San Francisco, USA). “Even for the current and longtime smoker, AF can still be avoided.”
Smoking is greatly associated with an increased risk of AF—an irregular and often rapid heart rhythm. It has potentially serious health consequences and is linked with a significant risk of stroke, heart failure and overall mortality. Rates of AF are also rising, creating a need to identify lifestyle changes that can reduce risk.
“There’s strong evidence that smoking increases the risk of AF, but the benefits of quitting smoking have been less certain,” Marcus continued. “We wanted to determine whether quitting smoking could lower a person’s risk of developing AF or if the risk would stay the same.”
The team analysed UK Biobank data on more than 146,700 current and former smokers. Participants’ smoking habits and health outcomes were tracked for roughly 12 years.
They found that former smokers had around a 13% lower risk of AF than people who were still smoking. Surprisingly, researchers also found that those who quit smoking during the study had an 18% lower risk of AF than people who smoke, showing a significantly lower risk than former smokers.
“This is likely a testament to the potency of reducing AF risk pretty shortly after quitting,” Marcus commented.
Previous research that looked at the connection between smoking and AF was observational, making it difficult to prove a causal relationship.
“While the current study is also observational, our findings lend credence to the idea that smoking may truly cause AF,” Marcus added.
The research team has acknowledged that study limitations include the possibility of recall bias in self-reported smoking status; the variability of the number of completed serial lifestyle questionnaires; and unmeasured confounding that may have contributed to the results, such as participant lifestyle or access to support in preventative health.
Future research could focus on explaining the mechanisms underlying the relationship between smoking and AF, potentially identifying new therapeutic targets to prevent and treat the condition.
