Cardialen has announced the publication of a first-in-human study in the Journal of the American College of Cardiology: Clinical Electrophysiology investigating its low-voltage MultiPulse therapy to terminate atrial fibrillation (AF). The study consisted of 42 patients who were indicated for AF ablation. In the efficacy portion of the study, MPT achieved 71% termination of AF episodes at energy levels deemed to be tolerable for patients (interquartile range of 0.14 to 1.21 Joules).
Fu Siong Ng, a clinical researcher at the National Heart & Lung Institute, Imperial College London, London, United Kingdom, stated: “Cardialen’s MPT therapy effectively terminated atrial fibrillation at energies known to be tolerated by patients. This therapy shows promise for treating AF in patients receiving an implantable defibrillator who may have or also develop AF.”
Atrial fibrillation is an irregular and rapid heart rate that can lead to patient discomfort and increased risk of stroke. Approximately 34 million patients suffer from this condition worldwide. Approximately 26% of implantable cardioverter defibrillator (ICD) patients, and 36% of cardiac resynchronization therapy defibrillator (CRT-D) patients, receiving an implantable cardiac defibrillator have, or will likely experience, atrial fibrillation. Cardialen seeks to develop a therapy for those patients already receiving an implantable CRT-D device.