A real-world study of smartwatch electrocardiography (ECG) tools for the detection of atrial fibrillation (AF) has found that the use of such devices is “challenging” in patients with abnormal ECGs, and could be aided by better algorithms and machine learning to provide more accurate diagnosis.
This is the conclusion of a paper by Hugo-Pierre Racine (Université Laval, Québec, Canada), Marc Strik (Bordeaux University Hospital, Bordeaux, France) and colleagues, published in the Canadian Journal of Cardiology, in which researchers examined the role of coexisting ECG anomalies in the accuracy of smartwatch ECG detection of AF.
“Earlier studies have validated the accuracy of the Apple Watch for the diagnosis of AF in a limited number of patients with similar clinical profiles,” said Strik, the study’s lead investigator. “We tested the accuracy of the Apple Watch ECG app to detect AF in patients with a variety of coexisting ECG abnormalities.”
The study included 734 consecutive hospitalised patients. Each patient underwent a 12-lead ECG, immediately followed by a 30-second Apple Watch recording. The smartwatch’s automated single-lead ECG AF detections were classified as “no signs of AF,” “AF,” or “inconclusive reading.” Smartwatch recordings were given to an electrophysiologist who conducted a blinded interpretation, assigning each tracing a diagnosis of “AF,” “absence of AF,” or “diagnosis unclear.” A second blinded electrophysiologist interpreted 100 randomly selected traces to determine the extent to which the observers agreed.
In approximately one in every five patients, the smartwatch ECG failed to produce an automatic diagnosis. The risk of having a false positive automated AF detection was higher for patients with premature atrial and ventricular contractions (PACs/PVCs), sinus node dysfunction, and second- or third-degree atrioventricular-block. For patients in AF, the risk of having a false negative tracing (missed AF) was higher for patients with ventricular conduction abnormalities (interventricular conduction delay) or rhythms controlled by an implanted pacemaker.
The cardiac electrophysiologists had a high level of agreement for differentiation between AF and non-AF. The smartphone app correctly identified 78% of the patients who were in AF and 81% who were not in AF. The electrophysiologists identified 97% of the patients who were in AF and 89% who were not.
Patients with PVCs were three times more likely to have false positive AF diagnoses from the smartwatch ECG, and the identification of patients with atrial tachycardia (AT) and atrial flutter (AFL) was very poor.
“These observations are not surprising, as smartwatch automated detection algorithms are based solely on cycle variability,” Strik noted, explaining that PVCs cause short and long cycles, which increase cycle variability. “Ideally, an algorithm would better discriminate between PVCs and AF. Any algorithm limited to the analysis of cycle variability will have poor accuracy in detecting AT/AFL. Machine learning approaches may increase smartwatch AF detection accuracy in these patients.”
In an accompanying editorial, Andrés F Miranda-Arboleda and Adrian Baranchuk (Kingston Health Science Center, Kingston, Canada) observed that this is the first “real-world” study focusing on the use of the Apple Watch as a diagnostic tool for AF.
“It is of remarkable importance because it allowed us to learn the performance of the Apple Watch in the diagnosis of AF is significantly affected by the presence of underlying ECG abnormalities. In a certain manner, the smartwatch algorithms for the detection of AF in patients with cardiovascular conditions are not yet smart enough. But they may soon be,” Miranda-Arboleda and Baranchuk said.
“With the growing use of smartwatches in medicine, it is important to know which medical conditions and ECG abnormalities could impact and alter the detection of AF by the smartwatch in order to optimise the care of our patients,” Strik said. “Smartwatch detection of AF has great potential, but it is more challenging in patients with pre-existing cardiac disease.”