Study finds over 2,000 excess cardiovascular deaths in England and Wales during pandemic


Research has identified 2,085 excess deaths in England and Wales linked to cardiovascular disease during the peak of the COVID-19 pandemic. On average, that is 17 deaths each day over four months from 2 March to 30 June 2020. The scientists believe the excess deaths were caused by people not seeking emergency hospital treatment for a heart attack or other acute cardiovascular illness requiring urgent medical attention, either because they were afraid of contracting COVID-19 or were not referred for treatment.

The findings, based on an analysis of the information contained on death certificates, have ben published in the journal Heart.

Over the same period, there was a sharp rise in the proportion of people who died at home or in a care home from acute cardiovascular diseases, the research team has found. Chris Gale, professor cardiovascular medicine, University of Leeds, Leeds, UK, said: “It is entirely plausible that a number of deaths could have been prevented if people had attended hospital quickly when they began to experience their heart attack or stroke. The sad irony is that previous research we have undertaken showed that nationwide heart attack services remained fully operational and continued to deliver high quality care during the peak of the pandemic.”

The investigation was carried out by a team of data scientists and clinicians, led by academics at the University of Leeds, and included collaborators from Keele University, NHS Digital, the Office for National Statistics, Barts Health NHS Trust, and University College London. This is the third major study from academics investigating how the peak of the COVID-19 pandemic affected emergency cardiovascular services.

Jianhua Wu, associate professor in the School of Medicine at Leeds, led the latest study. He said: “This study is the first to give a detailed and comprehensive picture of what was happening to people who were acutely ill with cardiovascular disease cross England and Wales. It reveals a large number of excess deaths. The findings will help government and the NHS to develop messages that ensure people who are very ill do seek help.”

The analysis looked at the information that is collected when a death certificate is issued. It details the cause of death and where the person died. To provide baseline data, the study looked at cardiovascular deaths from the 1 January 2014 through to 30 June 2020.

In the four months from 2 March, 2020—when the first COVID-19 death was registered in the UK—to 30 June, there were 28,969 cardiovascular deaths. That was compared to the average number of deaths seen for the same period over each of the previous six years. It was 8%, revealing 2085 excess deaths. The excess cardiovascular deaths began to emerge in late March 2020 and peaked in early April.

Previous studies by the researchers, published in The Lancet and European Heart Journal‒Quality of Care and Clinical Outcomes, have revealed that the number of people arriving at hospital with a heart attack fell sharply, with some units seeing just over half the expected number of cases.

This latest analysis has revealed a shift in where people were dying. There were proportionately fewer deaths in hospital compared to the baseline data: 53.4% versus 63%. Proportionately more deaths were happening at home: 30.9% vs. 23.5%, and in care homes: 15.7% v 13.5%. Excess deaths were disproportionately happening at home, up by 35% when compared with what would be expected, and in care homes, up by 32% increase. In the paper, the scientists noted: “This ‘displacement of death’, most likely, signifies that the public either did not seek help or were not referred to hospital during the pandemic…”

The location of excess daily deaths: at home, in care homes and in hospital from February 2020 through to the end of June. Lockdown began on 23 March. Excess deaths at home and in care homes rise sharply from the middle of March—while excess non-COVID deaths in hospital fall.

For people in care homes and hospices, the most prevalent cause of death was stroke and heart failure. For those who died at home, it was heart attack or heart failure. Pulmonary embolism and cardiogenic shock, where the heart can’t supply enough blood to the body, were the most frequent causes of death for those who died in hospital.

Gale said: “Our study has revealed that people who died at home were most likely to have had a heart attack. This is further support for the speculation that many people were staying away from hospital even though they were very ill with an acute cardiovascular illness. The reality of an untreated heart attack is that it will cause complications—and that will either lead to death, heart failure or life-threatening heart rhythms. The messages that went out at the time of lockdown were important. The NHS did need protecting from a potential surge of COVID-19 cases. But some people may have taken the messaging to mean that the NHS was not able to cope if they had a medical emergency, or that hospitals were a place where they would catch the contagion. As the NHS prepares for any future wave of COVID-19, it needs to ensure people clearly understand that hospitals are open and have processes in place to minimise the risks of patients becoming infected with COVID-19.”


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