Arrhythmia mapping system improves freedom from AF during ablation


Vektor Medical has announced that use of the vMap arrhythmia mapping system during complex atrial fibrillation (AF) ablation was associated with significantly improved freedom from atrial arrhythmias compared with standard-of-care pulmonary vein isolation. Results will be presented at the Biomarkers and Personalized Medicine in Cardiovascular Disease Symposium (25 March, La Jolla, USA).

“Using vMap, we were able to efficiently identify AF source locations and then successfully ablate target sites, resulting in a significantly higher success rate than in the control group,” stated David Krummen, (University of California San Diego, San Diego, USA) co-founder of Vektor Medical. “Traditionally, ablation success rates for the complex AF patients included in this study have been disappointing, and mechanistic insights which may guide ablation to atrial fibrillation-sustaining sites are desperately needed. While additional studies will be needed to validate the findings in a larger population, the high rate of arrhythmia-free survival seen in the study arm at six months is extremely encouraging.”

In a novel feasibility study, patients who received targeted AF-driver ablation, guided by the vMap arrhythmia mapping system, as well as PVI had significantly higher rates of freedom from AF and atrial tachycardia (AT) than the control patients undergoing pulmonary vein isolation alone at a median follow-up of six months. The findings add to the growing body of evidence that demonstrates vMap’s exciting potential to improve treatment of atrial fibrillation and a range of other arrhythmias. For the study, complex atrial fibrillation ablation was defined as patients with persistent AF, recurrent AF after prior ablation, and atrial fibrillation associated with a second atrial arrhythmia.

The study included a treatment arm of 15 AF patients who received successful PVI and AF driver site ablation guided by vMap. The control arm consisted of 54 persistent and paroxysmal AF patients who had successful PVI. The study found that additional AF driver site ablation guided by the vMap system was associated with an 87.5% freedom from all atrial arrhythmias compared with the control arm’s 58% arrhythmia-free survival (p=0.043). Additional multicentre studies are planned to further validate the study results.

“I absolutely believe that treatment for AF is not one size fits all and these results are another reminder that we, as electrophysiologists, can continue to do better in our treatment plan for atrial fibrillation,” said Alborz Hassankhani (Scripps Health, La Mesa, USA) an electrophysiologist not associated with the study. “While for many the standard of care may be pulmonary vein isolation, these results suggest that targeted driver-site ablation may help deliver the superior results our patients deserve. The fact that we see so many recurrences following ablation tells me that there is something fundamental missing in our approach to this disease. vMap seems to provide a guide to a more individualised approach. The results speak for themselves.”


Please enter your comment!
Please enter your name here